Since the middle of the 20th century, suicidology, as a group of disciplines working to understand and prevent suicide, has reinforced the long-held view that suicide is caused first and foremost b...

Summary Using the neurological syndrome kuru as a frame, Warwick Anderson examines the social dynamics and material culture of its medical investigation among the Fore people conducted by D. Carleton Gajdusek beginning at midcentury. The Collectors of Lost Souls: Turning Kuru Scientists into White Men uses a postcolonial framework to complicate dominant/subordinate binaries and diffusionist accounts of indigenous contacts with medical science. Anderson proposes that colonies are specific sites of production of medical knowledge. He draws a distinction between traditional and (...) advanced economies in regard to individual rights to make an argument in support of context-specific ethical regulation for medical research and suggests a role for historians of science in interrogating the process of globalisation. (shrink)

Summary Watters questions the universality of mental illness and warns of the harms that accompany the exportation of Western typologies to non-Western cultures. He is particularly concerned that these effects will be exacerbated by the upcoming revisions of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Building on his examination of non-Western practices, Watters exposes the historical instability of mental health classifications in North America to question the validity of current DSM categories. Although Watters' warnings about the dangers of (...) the globalisation of the DSM are persuasive, they may be overreaching as our examination of the successful incorporation of Western created autism services, information, and interventions in the developing world suggests. (shrink)

In El Salvador from 1978 to 1988, contraceptive use among married women 15–44 years of age increased from 34% to 47%, and the total fertility rate declined from 6·3 to 4·6 children per woman. Most of this change took place from 1978 to 1985. Sterilization is the most prevalent method used, but nearly one-half of the women who are sterilized did not use any contraception before their operation. Few young couples use reversible methods of contraception to space births or delay (...) the start of childbearing. On average, women wait 8 years after marriage and have nearly three children before they use contraception. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Employing the National Institute of Mental Health-funded Prevention of Suicide in Primary Care Elderly Collaborative Trial as a case study, we discuss 2 sets of ethical issues: obtaining informed consent for a clinic-based intervention study and using treatment as usual (TAU) as the control condition. We then address these ethical issues in the context of the debate about the quality improvement efforts of health care organizations. Our analysis reveals the tension between ethics and scientific integrity involved with using TAU as (...) a control condition and the difficulty in designing high-quality research in a community-based setting. (shrink)

Although sensorimotor contingencies may explain visual perception, it is difficult to extend this concept to speech perception. However, the basic concept of perception as active hypothesis testing using attention does extend well to speech perception. We propose that the concept of sensorimotor contingencies can be broadened to sensory-attentional contingencies, thereby accounting for speech perception as well as vision.

There is considerable evidence that the hippocampal system contributes both to (1) the temporary maintenance of memories and to (2) the processing of a particular type of memory representation. The findings on amnesia suggest that these two distinguishing features of hippocampal memory processing are orthogonal. Together with anatomical and physiological data, the neuropsychological findings support a model of cortico-hippocampal interactions in which the temporal and representational properties of hippocampal memory processing are mediated separately. We propose that neocortical association areas maintain (...) shortterm memories for specific items and events prior to hippocampal processing as well as providing the final repositories of long-term memory. The parahippocampal region supports intermediate-term storage of individual items, and the hippocampal formation itself mediates an organization of memories according to relevant relationships among items. Hippocampal-cortical interactions produce (i) strong and persistent memories for events, including their constituent elements and the relationships among them, and (ii) a capacity to express memories flexibly across a wide range of circumstances. (shrink)

Recent literature on Kant’s Opus postumum has typically focused on two parts of the drafts: the ether proofs and the Selbstsetzungslehre. Eckart Förster’s interpretation is representative of this tendency and, moreover, presents the Selbstsetzungslehre as the culmination of Kant’s late project. By contrast, I argue that the drafts of fascicles X/XI, written in between the ether proofs and the Selbstsetzungslehre, are of primary importance for understanding the Opus postumum. Through a close reading of a page from fascicle XI, I show (...) that Kant attempts to resolve problems internal to the Selbstsetzungslehre and the ether proofs by presenting a transition from the former to the latter. I advocate a renewed appreciation of the centrality of fascicles X/XI, insofar as the Opus postumum drafts aspire to a science of transition. (shrink)

This unpublished 1990 preprint argues that a crucial distinction in discussions of the many-worlds interpretation of quantum mechanics (MWI) is that between versions of the interpretation positing a physical multiplicity of worlds, and those in which the multiplicity is merely psychological, and due to the splitting of consciousness upon interaction with amplified quantum superpositions. It is argued that Everett's original version of the MWI belongs to the latter class, and that most of the criticisms leveled against the MWI, in particular (...) that it is illogical or incoherent, are not valid against such "psychological-multiplicity" versions. Attempts to derive the quantum-mechanical probabilities from the many-worlds interpretation are reviewed, and Everett's initial derivation is extended in an attempt to show that these are the unique possible probabilities. But there remains a challenge for proponents of the MWI: to show that their interpretation requires probabilities, rather than merely nonprobabilistic indeterminacy. A 2002 preface, revised in 2004, briefly discusses the extent to which I still agree with the claims in the paper. While its derivation of probabilities used, and failed to justify, noncontextuality, I still agree with the paper's general interpretation of the MWI, though not with the MWI itself. (shrink)

Søren Kierkegaard, the nineteenth-century Danish philosopher rediscovered in the twentieth century, is a major influence in contemporary philosophy, religion, and literature. He regarded Either/Or as the beginning of his authorship, although he had published two earlier works on Hans Christian Andersen and irony. The pseudonymous volumes of Either/Or are the writings of a young man and of Judge William. The ironical young man's papers include a collection of sardonic aphorisms; essays on Mozart, modern drama, and boredom; and "The Seducer's Diary." (...) The seeming miscellany is a reflective presentation of aspects of the "either," the esthetic view of life. Part II is an older friend's "or," the ethical life of integrated, authentic personhood, elaborated in discussions of personal becoming and of marriage. The resolution of the "either/or" is left to the reader, for there is no Part III until the appearance of Stages on Life's Way. The poetic-reflective creations of a master stylist and imaginative impersonator, the two men write in distinctive ways appropriate to their respective positions. (shrink)

Using a result of H. Hanche-Olsen, we show that (subject to fairly natural constraints on what constitutes a system, and on what constitutes a composite system), orthodox finite-dimensional complex quantum mechanics with superselection rules is the only non-signaling probabilistic theory in which (i) individual systems are Jordan algebras (equivalently, their cones of unnormalized states are homogeneous and self-dual), (ii) composites are locally tomographic (meaning that states are determined by the joint probabilities they assign to measurement outcomes on the component systems) (...) and (iii) at least one system has the structure of a qubit. Using this result, we also characterize finite dimensional quantum theory among probabilistic theories having the structure of a dagger-monoidal category. (shrink)

The influence of Kant's philosophy has been, and continues to be, so profound and so widespread as to have become imperceptible. Philosophical inquiry within both the ‘analytic’ and the ‘continental’ traditions is unthinkable without the lexical and conceptual resources bequeathed by Kant. Even outside philosophy, in the humanities, social sciences and natural sciences, Kantian concepts and structures of argument are ubiquitous. Anyone practicing literary or social criticism is contributing to the Kantian tradition; anyone reflecting on the epistemological implications of their (...) work will find themselves doing so within parameters established by Kant. Indeed, many contemporary debates, whether in aesthetics, literary or political theory, show a peculiar tendency to mutate into disputes in Kant exegesis. All in all, in the less than 200 years since the death of its author, Kantian philosophy has established itself as an indispensable point of intellectual orientation. (shrink)

Aristotle's Account of the Virtue of Temperance in Nicomachean Ethics III. 1 o- 11 HOWARD J. CURZER 1. INTRODUCTION maNY ?ONTEMPOX~RY SOCIAL eROBL~S arise from inappropriate indulgence in food, drink, and/or sex. Temperance is the Aristotelian virtue which governs these three things, and Aristotle's account of temperance contains important insights and useful distinctions. Yet Aristotle's account of temperance has been surprisingly neglected, despite the resurgence of virtue ethics. I shall remedy this neglect by providing a passage- by-passage commentary on (...) Aristotle's account of temperance in Nicomachean Ethics III. lO-11. I shall describe the sphere of temperance and Aristotle's distinctions among the character traits of temperance, self-indulgence, insensi- bility, continence, incontinence, and brutishness. I shall also describe the pas- sions and parameters of temperance and argue that Aristotle's account of temperance is compatible with his doctrine of the mean. My interpretation includes several controversial claims. For example, I maintain that Aristote- lian temperance governs not only the enjoyment of certain tactile pleasures, but also the desire for these pleasures. Aristotle's account clashes with common sense and with his own architec- tonic at several points. For example, he maintains that a person is intemperate only if he or she goes wrong.. (shrink)

There are two different ways of understanding the notion of ‘ontological commitment ’. A question about ‘what is said to be’ by a theory or ‘what a theory says there is’ deals with ‘explicit’ commitment ; a question about the ontological costs or preconditions of the truth of a theory concerns ‘implicit’ commitment. I defend a conception of ontological commitment as implicit commitment, and argue that existentially quantified idioms in natural language are implicitly, but not explicitly, committing. I use the (...) distinction between the two kinds of ontological commitment to diagnose a flaw in a widely used argument to the effect that existential quantification is not ontologically committing. (shrink)

Background: Current practice frequently fails to provide care consistent with the preferences of decisionally-incapacitated patients. It also imposes significant emotional burden on their surrogates. Algorithmic-based patient preference predictors (PPPs) have been proposed as a possible way to address these two concerns. While previous research found that patients strongly support the use of PPPs, the views of surrogates are unknown. The present study thus assessed the views of experienced surrogates regarding the possible use of PPPs as a means to help make (...) treatment decisions for decisionally-incapacitated patients. -/- Methods: This qualitative study used semi-structured interviews to determine the views of experienced surrogates [n=26] who were identified from two academic medical centers and two community hospitals. The primary outcomes were respondents’ overall level of support for the idea of using PPPs and the themes related to their views on how a PPP should be used, if at all, in practice. -/- Results: Overall, 21 participants supported the idea of using PPPs. The remaining five indicated that they would not use a PPP because they made decisions based on the patient’s best interests, not based on substituted judgment. Major themes which emerged were that surrogates, not the patient’s preferences, should determine how treatment decisions are made, and concern that PPPs might be used to deny expensive care or be biased against minority groups. -/- Conclusions: Surrogates, like patients, strongly support the idea of using PPPs to help make treatment decisions for decisionally-incapacitated patients. These findings provide support for developing a PPP and assessing it in practice. At the same time, patients and surrogates disagree over whose preferences should determine how treatment decisions are made, including whether to use a PPP. These findings reveal a fundamental disagreement regarding the guiding principles for surrogate decision-making. Future research is needed to assess this disagreement and consider ways to address it. (shrink)

This paper provides an account of reparations in general and then presents briefly one explanation of why many present day African Americans believe they are entitled to reparations from the U.S. Government.This explanation should not be seen as a final justification, but only as an indication why the demand for reparations for AfricanAmericans might be seen a plausible. Next, if it is reasonable to assume that reparations to African Americans are plausible, I then go onto explain why reparations might be (...) necessary to fill the breech that is perceived to exist between many African Americans and their government. This explanation will involve an examination of the relationship between three concepts: forgiveness, reconciliation, and reparations. Then I explore why an apology or reparations for slavery and Jim Crow might be necessary for reconciliation between many African Americans and their government. Finally, I examine the contention that the legislative process can be used to obtain an apology or reparations from the government. (shrink)

Once again it is becoming fashionable to ask ‘What character traits are virtues?’ Naturally, it behooves us to try to recapture the insights of our predecessors, as well as forging ahead on our own. In this paper I shall examine one such insight.

We develop a logical modelling approach to describe evolvable computational systems. In this account, evolvable systems are built hierarchically from components where each component may have an associated supervisory process. The supervisor's purpose is to monitor and possibly change its associated component. Evolutionary change may be determined purely internally from observations made by the supervisor or may be in response to external change. Supervisory processes may be present at any level in the component hierarchy allowing us to use evolutionary behaviour (...) as an integral part of system design. We model such systems in a revision-based first-order logical framework in which supervisors are modelled as theories which are at a logical meta-level to the theories of their components. This enables evolutionary change of the component to be induced by revision-based changes of the supervisor at the meta-level. In this way, the intervention required in evolutionary change is modelled purely logically. The hierarchical component-based structure is fairly intricate so we present the basic ideas firstly in a simple setting, the well-known blocks world, before introducing tree-based structures to represent component hierarchies. We also introduce some techniques for establishing the behaviour of evolvable systems specified in this logical framework. The ideas and concepts are driven by example throughout. We conclude with a more substantial example, that of a simple model of an evolvable system of automated bank teller machines. (shrink)

I propose and defend a novel view called “de se consequentialism,” which is noteworthy for two reasons. First, it demonstrates—contra Doug Portmore, Mark Schroeder, Campbell Brown, and Michael Smith, among others—that agent-neutral consequentialism is consistent with agent-centered constraints. Second, it clarifies the nature of agent-centered constraints, thereby meriting attention from even dedicated nonconsequentialists. Scrutiny reveals that moral theories in general, whether consequentialist or not, incorporate constraints by assessing states in a first-personal guise. Consequently, de se consequentialism enacts constraints through the (...) very same feature that nonconsequentialist theories do. (shrink)

D. Dieks has proposed a semantical rule which he claims yields a realistic interpretation of the formalism of quantum mechanics without the projection postulate. I argue that his proposal is unacceptable because it violates a natural requirement of psychophysical parallelism. His "semantical rule" is not an acceptable interpretive rule because it does not identify structures in the theory with structures in our experience, but postulates a merely probabilistic relationship between the two. Dieks' interpretation is contrasted with Everett's relative state interpretation, (...) which attempts the same task but respects psychophysical parallelism. (shrink)

The relationship between mission and spirituality for sincere disciples of Jesus involves dimensions that include the biblical, the theological, the historical, the missiological, the spiritual, and the practical. This article will offer a contribution to the biblical discussion, specifically from the Fourth Gospel and through the lens of the motif of agency. This motif can inform what Jesus meant when he said, “Just as the Father has sent me, so I send you”.1 As a result, conclusions can be drawn in (...) regard to the place of mission in Johannine spirituality and discipleship. (shrink)

Having for thirty years believed and taught the doctrine of phlogiston… I for a long time felt inimical to the new system, which represented as absurd that which I hitherto regarded as sound doctrine; but this enmity… springs only from force of habit… [Black to Lavoisier, 1791]This paper is abstracted from a forthcoming book which defends a particular answer to the question of just what it is that shifts when a paradigm shifts. The claim is that what shifts are habits (...) of mind. And in particular the claim is that the most striking cases of paradigm shift will characteristically turn on a shift in some single, uniquely critical, habit of mind: the barrier. An account of a radical discovery — discovery that prompts the Kuhnian symptoms of incommensurability, so that intuitions that seem irresistible to some seem perverse to their rivals — then characteristically turns on how some individual got past the barrier (escaped the critical habit of mind), while at least for a while others could not do so. (shrink)

We often find ourselves in situations where it is up to us to make decisions on behalf of others. How can we determine whether such decisions are morally justified, especially if those decisions may change who it is these others end up becoming? In this paper, I will evaluate one plausible kind of justification that may tempt us: we may want to justify our decision by appealing to the likelihood that the other person will be glad we made that specific (...) choice down the line. Although it is tempting, I ultimately argue that we should reject this sort of appeal as a plausible justification for the moral permissibility of our vicarious decisions. This is because the decisions that we make on behalf of another may affect the interests and values that that person will hold in the future. As I will show, this complicates the justificatory relationship between present decisions and future attitudes, since the latter can depend on the former. This is not to say that the predicted future attitudes of others can play no significant role in justifying our decisions on others’ behalf. Rather, appealing to the future attitudes in our moral justifications may play an important role in our practical thinking but only when we consider the future attitudes of all relevant possible futures. (shrink)

Abstract: It is often claimed that realists about universals must be either “platonists,” holding that universals lack spatio-temporal location, or “aristotelians,” asserting that universals are located where their instances are. What’s more, both camps agree that locatedness or unlocatedness is part of the essential nature of universals; consequently, aristotelians say that universals cannot exist un located, and platonists allege that universals cannot be located. Here I argue that the dispute may be resolved by synthesizing the most attractive features of each (...) position. I claim that universals are located at their instances when instantiated by particulars which themselves possess a spatio-temporal location; however, un instantiated universals exist without location. This has the consequence that it will often be a contingent matter whether a given universal has a location, if the universal is only contingently instantiated. Nevertheless, I claim, objections to this position may be overcome. (shrink)